Determination of Folic Acid in Pharmaceutical Preparations by Square-Wave Voltammetry Using a Boron-Doped Diamond Electrode

Page: 788

K. Cinková, P. Šatkovská, and Ľ. Švorc

Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava

Keywords: folic acid, boron-doped diamond electrode, square-wave voltammetry


Electrochemical behavior of folic acid (FA) was studied by cyclic voltammetry. An irreversible oxidation peak of FA was obtained at +0,85 V (Ag/AgCl, pH 5.0). The current dependence for square-wave voltammetry was linear at 1.0·10–7 – 17·10–4 M FA with a low detection limit of 3.0·10–8 M and good repeatability (RSD 2.8 %, n = 10). The method was used in analysis of tablets with recoveries 101.5 and 103.1 % and the determined values outside the confidence interval P = 95 %. The method is an alternative to widely used chromatographic methods.


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