Potential Endocrine Activity of Benzonitrile Herbicides

Page: 471

P. Lovecká, M. Thimová, and K. Demnerová

Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague

 

This review focuses on the estrogenic activity of the benzonitrile herbicides – bromoxynil, chloroxynil, dichlobenil and ioxynil and their microbial metabolites – acids (such as 3,5-dibromo-4-hydroxybenzoic acid and its amide). Some of their metabolites are very persistent. The estrogenic activity of the benzonitrile herbicides and their metabolites were studied using the mutant strain of Saccharomyces cerevisiae BMA64-1A. However, their estrogenic activity was not proved.

 

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