Advances in Studies of Insulin Interaction with Its Receptor

Page: 368

L. Žáková and J. Jiráček

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague


Until recently, despite decades of intensive research, the exact mode of interaction of insulin with its membrane receptor remained elusive. However, recent advances achieved with insulin analogues and crystallographic studies with the insulin receptor provided a first insight into the interaction of insulin with its primary binding site on the insulin receptor. This review describes the story of insulin research at the above Institute.


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