Mechanism of Base Excision with the hOGG1 DNA Repair Enzyme

Page: 364

J. Šeberaa, J. Fukala, V. Sychrovskýa, L. Trantírekb, and Y. Tanakac

a Department of Molecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, b Central European Institute of Technology, Masaryk University, Brno, Czech Republic, c Division of Pharmaceutical Chemistry, Tohoku University, Aobayama, Aoba-ku, Sendai, Japan


This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.


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