Utilizing Self-Emulsifying Drug Delivery Systems in Drug Solubility and Bioavailability Improvement

Page: 956

L. Seilerováa, V. Sieberováa, B. Kratochvíla, and D. Vetchýb

a Department of Solid State Chemistry, Institute of Chemical Technology, Prague, b Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno

 

Liphophilic formulations of pharmaceuticals are very promising methods of drug solubility improvement. Four types of the formulations are available: Self-emulsifying drug delivery systems (SEDDS) consist of oils, surfactants and cosolvents where the pharmaceutical ingredient are dissolved. These systems form o/w emulsions which can be administered in tablets, soft or hard gelatin capsules. The effectivity of SEDDS depends on many parameters, such as excipients or emulsion droplet size.

 

Full text (PDF)