Voltammetric Determination of Adrenaline in Human Urine Using Boron-Doped Diamond Film Electrode
Institute of Analytical Che¬mistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava
An unmodified boron-doped diamond (BDD) electrode was used in combination with square-wave voltammetry (SWV) in a simple, rapid and inexpensive method for the detection and determinativ of adrenaline. A low detection limit of 2•107 mol l1 attained on BDD electrode was due to a very high signal-to-noise (S/N) ratio. The proposed procedure was applied to analysis of human urine spiked with adrenaline giving good recovery values. Matrix effects did not present any significant interference. BDD electrode may be used as a sensitive drug sensor in clinical analysis of various biologically active compounds and may replace complex and expensive chromatographic and spectral methods. Howe¬ver, the usefulness of this method can be limited in clinical analysis in the presence of other drugs in urine, e.g. ascorbic acid and uric acid.
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