In-vitro Bioavailability of Hazardous Elements from Inhaled Urban Particulate Matter

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K. Kašparovskáa,b, J. Szákováb, J. Sysalovác, P. Tlustošb, and P. Svobodaa

a Institute of Physiology, Academy of Science of the Czech Republic, Prague, b Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Prague; c AAS Laboratory, Institute of Chemical Technology, Prague


An in vitro test simulating release of elements from inhaled particles using artificial lung fluids was used in estimation of bioavailability of hazardous elements (Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn). The extractable Al, Cr, Pb, and Fe did not exceed 1 %. The mobility of the elements was affected by the extractants used, incubation time and/or element properties. Whereas no significant differences between the extractants were found for As and Cr, higher extractability of the other elements was observed depending on the artificial lung fluid.


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