Conformational Study of the Antimicrobial Peptide Melectin by Circular Dichroism Methods
a Department of Analytical Chemistry, Institute of Chemical Technology, Prague, b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague
Antimicrobial peptides are considered as promising supplements to or substitutes for conventional antibiotics due to their different mechanisms of action. Biological activities of antimicrobial peptides are influenced by their conformations. The solution conformations of 18 amino acid residues peptide melectin (MEP) and its synthetic analogues including C-terminal and N-terminal fragments were studied using electronic and vibrational circular dichroism spectroscopies.
Full text (PDF)