New Co-processed Dry Binders Based on Lactose in Direct Compression of Tablets

Page: 66

J. Mužíková and K. Holubová

Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové


The paper evaluates and compares the strength and disintegration time of tablets and the energy profile of compression in dependence on compression force in the co-processed dry binders LubriToseTM SD and LubriToseTM AN. These substances are further compared in these parameters with the physical mixtures of the pertinent lactoses with various lubricants in a concentration of 4 %. The lubricants employed included glycerol monostearate, magnesium stearate, Poloxamer 407, and sodium stearyl fumarate.


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