Determination of Anti-Cathepsin-D Antibodies in Human Blood Sera of Oncological Patients

Page: 769

I. Machováa,b, J. Zídkováb, D. Springerc, V. Větvičkad, and M. Fusekb

aInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Prague, bDepartment of Biochemistry and Microbiology, Institute of Chemical Technology, Prague, c Department of Clinical Biochemistry and Laboratory Medicine, First Faculty of Medicine, Charles University, Prague), d Department of Pathology, University of Louisville, Louisville, USA


In this study the levels of auto-antibodies formed against the activation peptide of procathepsin D were determined by the ELISA method using a synthetic multiantigen peptide containing the N-terminal amino acid sequence of the activation peptide of procathepsin D as a coating antigen. Based on the results auto-antibodies cannot be considered suitable cancer markers.


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