Parallel Determination of Voriconazole and Posaconazole in Plasma by HPLC

Page: 677

L. Maláškováa, J. Winterováb, M. Dastycha, Z. Ráčilb, I. Kocmanovác, M. Toškováa, and J. Mayerb

a Department of Clinical Biochemistry and Hematology, b Department of Internal Medicine and Hematooncology, c Department of Clinical Microbiology, all University Hospital, Brno

 

Voriconazole and posaconazole are azole broad-spectrum pharmaceuticals used in treatment and prophylaxis of invasive fungal infections. Determination of both the antifungals in blood plasma in the course of treatment makes it possible to achieve optimal dosing. Our aim was to integrate voriconazole and posaconazole monitoring in the treatment of fungal infections in hematooncological patients. At present the simple and rapid ultra performance liquid chromatography (UPLC) monitoring of both the antifungals is a part of daily routine.

 

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