Animal Lipoxygenases – Mechanism of Catalysis in Relation to Formation of Biologically Active Eicosanoids

Page: 639

P. Hoffman, L. Bezáková, I. Holková, M. Pekárová, and M. Obložinský

Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic


Lipoxygenases form a family of nonheme iron-containing enzymes involved in the lipid peroxidation processes. They participate, together with cyclooxy¬genases and cytochrome P-450, in the arachidonic acid metabolism, forming a group of cell signal molecules and secon¬dary messengers called eicosanoids. The lipoxygenase-catalyzed reactions are highly controlled processes media¬ted by steric shielding of substrate by bulky amino acid side chains in the reaction center. Equally important is the channeling of molecular oxygen and the anchoring of substrate in a substrate-binding cavity. From the viewpoint of development of new effective drugs, study of lipoxygena¬¬ses and bio¬logically active eicosanoids opens new horizons for affec-ting pathological processes.


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