Galactosyltransferase Inhibitors

Page: 283

I. Jambal, K. Kefurt, and J. Moravcová

Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague


Oligosaccharides in glycoconjugates form a sugar code in cell-cell recognition processes. Since galactosyltransferases are responsible for the biosynthesis of galactose-containing oligosaccharides, inhibitors of these enzymes are targets for drug design. In this review, the current state of the development of galactosyltransferase inhibitors, based on the donor and transition-state structures and bisubstrate analogues, is summarised.


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