Thermal Analysis in the Pharmaceutical Research and Drug Development

Page: 890

L. Seilerováa, H. Brusováb, B. Kratochvíla, and L. Krejčíkb

a Department of Solid State Chemistry, Institute of Chemical Technology, Prague, b Zentiva Co., Praha


Thermal analysis is a valuable method in pharmaceutical research. A wide range of thermal methods are used in drug development like thermogravimetry (TG), diffe¬rential thermal analysis (DTA), differential scanning calori¬metry (DSC) and other sensitive and specific methods. The present review deals with application of these me¬thods in characterization of drugs and excipients, such as their polymorph stability, glass transition temperature, purity analysis and compatibility of drugs.


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