Lipophilic Formulations for Increasing Bioavailability of Poorly Water-Soluble Drugs

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A. Franca, D. Vetchýa, L. Smilkováa, M. Rabiškováa, and B. Kratochvílb

a Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, b Department of Solid State Chemistry, Institute of Chemical Technology, Prague


This review describes a new trend in the formulation of dosage forms containing poorly water-soluble drugs - lipophilic solutions, dispersions, liposomes and nanoparticles - dealing also with their composition and manufacture. The dispersions are further divided into non-emulsifying, self-emulsifying, self-microemulsifying and self-nanoemulsifying drug delivery systems. The cited systems are able to form micro- and nanoemulsions in contact with gastric juices. Formulations containing lipophilic nanoparticles as well as micro- and nanoemulsions are easily absorbed. A system classifying lipid formulations according to the drug composition is also described. The system enables the taxonomy of lipophilic drugs to be made; it also tries to describe their further metabolic ways in the organism.


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