Case Study of Polymorphic Transformation

Page: 381

M. Hušáka and R. Gabrielb

aDepartment of Solid State Chemistry, Institute of Chemical Technology, Prague, bDepartment of Physical Chemistry, Faculty of Science, Palacký University Olomouc


Polymorphic system of two anhydrates (A and B forms) of N-(2-chloro-6methylphenyl)-2-[[6-(hydroxyethyl)- 1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5- thiazole carboxamide was characterized by X-ray powder diffraction, DSC and microscopy techniques. Basic crystal data of form A were obtained and crystal structure of form B was determined from X-ray synchrotron powder data.


Full text (PDF)