Mass Spectrometry in Cancer Diagnosis
a Microbiological Institute, Academy of Sciences of the Czech Republic, Prague, b Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacký University and Faculty Hospital, Olomouc, c Department of Analytical Chemistry, Faculty of Science, Palacký University, Olomouc
Tumor markers play an important role in cancer diagnostics. However, with the exception of selected fusion genes and proteins, there are no specific compounds for unambiguous cancer diagnosis. Oncologists must combine many markers to assess diagnosis, staging, prognosis and prediction of therapeutic response. Mass spectrometry (MS) is a powerful technique which can help to identify new biomarkers and/or to refine information about marker candidates. Recent years have witnessed new approaches in MS analysis for dicovery of cancer biomarkers. This review highlights some recent findings and trends in cancer diagnosis.
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