Separation of Quaternary Benzo[c]phenanthridine Alkaloids from Macleaya cordata

Page: 51

J. Vičara, M. Souralb, and J. Hlaváčb

aInstitute of Mediincal Chemistry and Biochemistry, bDepartment of Organic Chemistry, Palacký University, Olomouc

 

A cost-effective method for separation of sanguinarine and chelerythrine from commercial Macleaya cordata extract (sanguiritrin) is described. In the first step, the alkaloids are reduced with NaBH4 to dihydro derivatives, which are easily separated by column chromatography on silica gel with chloroform and chloroform-methanol elution. In the second step, the dihydro derivatives are photochemically oxidized to the title alkaloids.

 

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