Determination of Toxicity of Binary Mixtures Using Rat Hepatocytes

Page: 575

A. Pokorná, M. Tichý, J. Nerudová, J. Tumová, and I. Hanzlíková

National Institute of Public Health, Prague


Primary hepatocyte assay was used to determine acute toxicity of nickel(II) chloride - 3,4-dichloroaniline and nickel(II) chloride - sodium diclophenac mixtures. Although the components act by different mechanisms, their acute toxicity was almost additive; it decreased to zero in dependence on the molar ratio of the components. Toxicities of pollutants in environment may decrease due to interactions with other components.


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