Selected Methods of Modification of Biosensor Surfaces for Protein Immobilization

Page: 178

R. Kotlín and J. E. Dyr

Institute of Hematology and Blood Transfusion, Prague


Protein immobilization plays a crucial role in biosensor construction. Conformational changes take place during protein adsorption onto a solid surface. The conformational changes may cause a loss of biological activity and may lead to impairment of the sensor. This is why different immobilization techniques have been designed; some of them are commercially utilized. This article is an overview of methods of surface modification for noncovalent protein immobilization.


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